Over a dose range of 40 to 140 mg cisplatinm2 given as a bolus injection or as. In addition to cisplatin, its analogs, such as carboplatin and oxaliplatin, are. Survival median ncic swog carboplatin 110 weeks 86 weeks cisplatin 99 weeks 79 weeks 2year survival carboplatin 51. If cisplatin is used in combination therapy, the dose of cisplatin must be reduced.
Doses of greater than 100 mgm 2 of cisplatin are likely to cause moderate bone marrow toxicity in the form of suppression as well as nephrotoxicity. Cisplatin dosing, indications, interactions, adverse. Only few studies have focused on cisplatininduced cytotoxicity, oxidative stress and. Concurrent cisplatinbased radiotherapy and chemotherapy. Higher doses of cisplatin are being given in daycare, increasing the strain on the chemotherapy suites and pharmacy. Cisplatin is currently one of the most widely used anticancer drugs in the world.
Each 50 ml, 100 ml or 200 ml amber vial of cisplatin injection contains. May use concomitant amifostine to decrease nephrotoxicity. Cisplatin injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. Cisplatin cisplatin injection drug overview and uses for. It is given by injection into a vein common side effects include bone marrow suppression, hearing. Cisplatin injection description clinical pharmacology fda. Cisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to. Abraxane is 125 mgm2 intravenously over 3040 minutes on days 1, 8 and 15 of each 28day cycle. Transport of drugs to the inner ear is dependent on the molecular characteristics of the drug. Cisplatin for injection is indicated for the treatment of advanced ovarian cancer. Following completion of platinumbased therapy, treatment with alimta with or without pembrolizumab isadministered until disease progression or unacceptable toxicity. A total of 121 patients were randomized and 120 treated 60 per group. Anderson cancer center, 1515 holcombe boulevard, houston, tx 770304009, usa cisplatin is one of the most potent antitumor agents.
Patients underwent pretreatment in vitro chemoresponse testing precision therapeutics, inc. Cisplatin hydration for outpatients chemotherapy regimen. Slides were washed with pbs and paste coverslip using prolong gold antifade reagent. Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Molecular mechanisms of cisplatin cytotoxicity in acute. Caring for the patient receiving cisplatin in the outpatientambulatorycare setting is a challenging nursing responsibility. Paraplatin carboplatin for injection, usp is supplied as a sterile, lyophilized white powder available in singledose vials containing 50 mg, 150 mg, and 450 mg of carboplatin for administration by intravenous infusion. Because of increased understanding regarding those factors that most influence nephrotoxicity and the application of creative hydration protocols, the administration of cisplatin in the outpatient area is both safe and preferred. Risk factors risk factors that make some patients more susceptible to cisplatin induced nephrotoxicity include. Patients in the gemzar cisplatin gc arm received a median of 5 cycles and those in the etoposide cisplatin ec arm received a median of 4 cycles. Please refer to the full prescribing information for pembrolizumab and for. Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patients quality of life.
Cisplatin is one of the leading chemotherapy drugs currently. In two prospectively randomized, controlled studies conducted by the national cancer institute of canada, clinical trials group ncic and the southwest oncology group swog, 789 chemotherapy naive patients with advanced ovarian cancer were treated with carboplatin or cisplatin, both in combination with cyclophosphamide every 28 days for 6 courses before. Each 50 ml or 100 ml amber vial of infusion concentrate contains. Protective effects of hepatic stellate cells against cisplatininduced. Nausea was the worst for me, they gave me compazine and ataivan not sure of spelling alternating every 4 hours still had nausea but perhaps. Cisplatin is a platinumcontaining compound that acts as a dnacrosslinking agent and interferes with replication and transcription, culminating in apoptosis. A typical dose is 20 mgm 2 or more once every 3 to 4 weeks for treatment of cervical cancer cisplatin is used in combination with radiotherapy. Chemotherapy was given by intravenous infusion every 3 weeks for up to 6 cycles, in the absence of doselimiting chemotherapyrelated toxicities. Serum magnesium levels should be monitored in patients receiving cisplatin chemotherapy. Many combinations of cisplatin have been studied in phase 2 trials of patients with cervical cancer.
Package insert of accord healthcares cisplatin injection. As a single agent, cisplatin injection should be administered at a dose of 100 mgm 2 iv per cycle once every four weeks. Cisplatin prices, coupons and patient assistance programs. Im six years out and have some dings from the treatment but would do it again. It is generally considered as a cytotoxic drug which kills cancer cells by. Cspm2 hydration protocol for cisplatin chemotherapy.
Is there any good replacement drug for cisplatin as a. Cisplatin 1 mgml concentrate for solution for infusion. Cisplatin is used to treat various types of cancer. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Is caused by a defect in a gene called anaplastic lymphoma kinase alk and has spread to other parts of the body. Pharmacological intervention in the field of ototoxicity springerlink. In vitro chemoresponse to cisplatin and outcomes in. Cisplatin fda prescribing information, side effects and uses. Cisplatin kills cells including cancer cells and normal cells by causing abnormal linkages in dna, the genetic material of cells.
It is not known if zykadia is safe and effective in children. The effect of locally delivered cisplatin is dependent on an intact. Zykadia is a prescription medicine that is used to treat people with nonsmall cell lung cancer nsclc that. As a single agent, cisplatin cisplatin injection should be administered at a dose of 100 mgm 2 iv per cycle once every four weeks. Induces apoptosis in cancer cells, possibly via caspase3 activation. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers.
In order to for patients to be treated as a day case, the regimens have been modified as follows. Cisplatin hydration guidelines for outpatients introduction there is increasing demand to treat more patients as outpatients. It also belongs to a larger group of chemotherapy drugs known as alkylating agents. Existing studies on how to supplement magnesium during treatment with cisplatin have.
Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy. Cisplatin is a member of the alkylating agents drug class and is commonly used for anal cancer, bladder cancer, blood cell transplantation, and others. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. Iv hydration for cisplatin 4 therefore, magnesium repletion may attenuate cisplatininduced nephrotoxicity. Current strategy for cisplatin delivery bentham science. In certain references, cisplatin may be decreased by 50% in the setting of hemodialysis.
Due to the unprecedented nature of the covid19 pandemic, anyone reporting an adverse event andor a product complaint via phone, should you receive a network busy signal ie. The unlikely events surrounding the discovery of its anticancer activity, subsequent introduction into the clinic. Quercetin and cisplatin on colon cancer cells 2287 int j clin exp med 2016. At the recommended dosage, cisplatin should not be given more frequently. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Cisplatin does not undergo the instantaneous and reversible binding to plasma proteins that is characteristic of normal drug. Cisplatin for injection is indicated for the treatment of advanced testicular cancer. Cisplatin is an antitumor drug 6, highly used in treatment of different kinds of. Carboplatin carboplatin this product information is intended only for residents of the united states. Cisplatin for injection is a platinumbased drug indicated for the treatment of. Department of chemical engineering and materials science, wayne state university, detroit, usa. Had modified rnd, cisplatin, carboplatin, erbitux and taxol, and 33 rounds of radiation not an unusual treatment.
In combination therapy, cisplatin cisplatin injection and cyclophosphamide are administered sequentially. This medication is usually given by injection into a vein by a health care professional. The recommended dosage of cisplatin depends on your wellbeing, the anticipated effects of the treatment, and whether or not cisplatin is given on its own monotherapy or in combination with other agents combination chemotherapy. This cisplatin price guide is based on using the discount card which is accepted at most u. Nuclear import of cabl was shown to be necessary for dna damageinduced apoptosis 117. It is used alone or in combination with other medications to slow or stop cancer cell growth. For instance, most germ cell tumor trials would calculate with an i.
Cisplatin is a chemotherapy medication used to treat a number of cancers. Do not use pvc infusion containers or polyurethane infusions sets for preparation and administration of jevtana infusion solution. For directions for the administration of cyclophosphamide, refer to the cyclophosphamide package insert. Patients received 20 mgm 2day of cisplatin for 5 days and 80 mgm2day of etoposide or etoposide phosphate. Cumulative prior dose of cisplatin as a cause of the nephrotoxicity of. Cisplatin injection is a clear, colorless, sterile aqueous solution. This was a retrospective analysis of patients with cervical cancer seen at our institution between may 2009 and august 2011.
Cisplatin is part of a group of medications called platinum analogues. In combination therapy, cisplatin injection and cyclophosphamide are administered sequentially. Ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. You have selected the maximum number of product attributes 3 to compare. The ratios of cisplatin to total free ultrafilterable platni um in the plasma vary consdi erably between patients and range from 0. Cisplatin for injection is indicated for the treatment of advanced bladder cancer. In this study, we investigated the effects of hscs on cisplatininduced. Divided in 6 sections and 22 chapters, the book provides an uptodate account on topics such as the chemistry and.
Cellular responses to cisplatininduced dna damage hindawi. Cisplatin is stable under normal temperatures and pressures, but may transform slowly over time to the transisomer iarc 1981, akron 2009. Cisplatin cas 15663271, is a platinum coordination complex with potent antineoplastic activity. Carboplatin pharmacokinetics in a patient receiving. It is paramount for health care practitioners managing such patients to be aware of cisplatins ototoxic properties and the clinical signs to identify.
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